Partial cloning of SOX-11 and SOX-12, two new human SOX genes
نویسندگان
چکیده
منابع مشابه
Sex, Sox, and splicing
ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...
متن کاملIdentification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity.
Sox transcription factors play key regulatory roles throughout development, binding DNA through a consensus (A/T)(A/T)CAA(A/T)G sequence. Although many different Sox proteins bind to this sequence, it has been observed that gene regulatory elements are commonly responsive to only a small subset of the entire family, implying that regulatory mechanisms exist to permit selective DNA binding and/o...
متن کاملSOX gene expression in human osteoarthritic cartilage.
OBJECTIVE While the developmental role of the SOX transcription factors in fetal chondrocyte differentiation is well documented, much less is known about the expression of SOX family members in normal and osteoarthritic adult cartilage. Therefore, the aim of the present study was to present a thorough analysis of SOX gene expression in normal and osteoarthritic human adult cartilage. METHODS ...
متن کاملSox Neuro, a new Drosophila Sox gene expressed in the developing central nervous system
We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous system (CNS), from the early steps onwards. We present strong evidence that the early SoxN neuroectode...
متن کاملA comparison of the properties of So Sox - 1 and Sox - 2
in of e n factor containing a 79-amino-acid DNA-binding domain known as the HMG box (Capel and Lovell-Badge, 1993). Many genes have now been cloned on the basis of their homology to the HMG box of Sry and comprise the Sox gene family, for Sry-related HMG box-containing genes. Approximately 20 Sox genes have been found in mammals, with more being identified in other vertebrates and invertebrates...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1993
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/21.12.2943